Immunophenotype Predicts Outcome in Pediatric Acute Liver Failure
نویسندگان
چکیده
منابع مشابه
Chronic acetaminophen exposure in pediatric acute liver failure.
BACKGROUND Acetaminophen (N-acetyl-p-aminophenol [APAP]) is a widely used medication that can cause hepatotoxicity. We examined characteristics and outcomes of children with chronic exposure (CE) to APAP in the multinational Pediatric Acute Liver Failure (PALF) Study. METHODS A total of 895 children enrolled from 2002 to 2009 were grouped by APAP exposure history as: CE (received multiple dos...
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OBJECTIVES To determine short-term outcome for children with acute liver failure (ALF) as it relates to cause, clinical status, and patient demographics and to determine prognostic factors. STUDY DESIGN A prospective, multicenter case study collecting demographic, clinical, laboratory, and short-term outcome data on children from birth to 18 years with ALF. Patients without encephalopathy wer...
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Introduction Pediatric acute liver failure (PALF) is an aggressive clinical syndrome in which a previously healthy child rapidly loses hepatic function and can become critically ill within days [1,2]. The mortality rate has been reported as high as 70% without a liver transplant, which is the only curative treatment to date [3]. However, when the current criterion of an international normalized...
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BACKGROUND AND AIM Although establishing accurate prognosis in acute liver failure (ALF) is of paramount importance, prognostic scoring systems still fail to achieve success. The pediatric end-stage liver disease (PELD) score has been used as a predictor of mortality in children with chronic liver disease listed for liver transplantation (LT); however, experience with the PELD score in ALF is l...
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Acute liver failure (ALF) is characterized by a sudden and severe deterioration of liver function, typically mirrored by a marked increase of the international normalized ratio (INR) and hepatic encephalopathy (HE). Due to various possible causes hepatocytes get damaged via either apoptotic or necrotic pathways. Anticipating the natural prognosis of a patient with ALF is one of the most challen...
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ژورنال
عنوان ژورنال: Journal of Pediatric Gastroenterology & Nutrition
سال: 2013
ISSN: 0277-2116
DOI: 10.1097/mpg.0b013e31827a78b2